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世界初の二母性マウス誕生発生と文化のメカニズムを探る

世界初の二母性マウス誕生発生と文化のメカニズムを探る

Tomohiro KONO

CURRICULM VITAE

BIRTH & AGE	June 6, 1953, 50 years old
PROFESSION	Professor Tokyo University of Agriculture, Graduate School of Applied Bioscience
EDUCATION	1976 BS, Department of Animal Science, Tokyo University of Agriculture, 1982 PhD, Graduate School of Agriculture, Tokyo University of Agriculture

Positions and Honors

1982 to 1986
Postdoctoral Fellow, NODAI Research Institute, Tokyo

1987 to 1991
Lecturer, Tokyo University of Agriculture, NODAI Research Institute, Tokyo

1991 to 1995
Associate Professor, Tokyo University of Agriculture, NODAI Research Institute, Tokyo

1993 to 1994
Researcher, Experimental Embryology and Teratology Unit, MRC, London

1996 to present
Professor, Tokyo University of Agriculture, Department of Bioscience, TokyoAward

1993
The Shimarura Award from the Japanese Society for Study of Animal Reproduction

Progress of our study on parthenogenesis and genomic imprinting

1983

Surani et al., Nature,
E9.5

1996

Kono et al., Nature Genetics
E13.5

2002

Kono et al., Dev. Biology
E17.5

2004

Kono et al., Nature,
Adult parthenogenetic mouse “KAGUYA”

Selected peer-reviewed publications

1	Kono T, Obata Y, Wu Q, Niwa K, Ono Y, Yamamoto Y, Park ES, Seo JS, Ogawa H. Birth of parthenogenetic mice that can develop to adult. Nature 428, 860-864, 2004.
2	Teranishi T, Tanaka M, Kimoto S, Ono Y, Miyakoshi K, Kono T, Yoshimura Y. Rapid replacement of somatic linker histones with the oocyte-specific linker histone H1foo in nuclear transfer. Dev. Biol. 266, 78-86, 2004.
3	Ogawa H, Ono Y, Shimozawa N, Sotomaru Y, Katsuzawa Y, Hiura H, Ito M, Kono T. Disruption of imprinting in cloned mouse fetuses from embryonic stem cells. Reproduction 126, 549-557, 2003.
4	Nikaido I, Saito C, Mizuno Y, Meguro M, Bono H, Kadomura M, Kono T, Morris GA, Lyons PA, Oshimura M, Hayashizaki Y, Okazaki Y. Discovery of imprinted transcripts in the mouse transcriptome using large-scale expression profiling. Genome Res.13, 1402-1409, 2003.
5	Bao S, Ushijima H, Hirose A, Aono F, Ono Y, Kono T. Development of bovine oocytes reconstructed with a nucleus from growing stage oocytes after fertilization in vitro. Theriogenology 59, 1231-1239, 2003.
6	Shimozawa, N., Ono, Y., Kimoto, S., Hioki, K., Araki, Y., Shinkai, Y., Kono, T. and Ito, M. Abnormalities in cloned mice are not transmitted to the progeny. Genesis 34: 203-207, 2002.
7	Obata, Y., Kono, T. and Hatada, I. Maturation of mouse fetal germ cells in vitro. Nature 418, 497-498, 2002.
8	Bao, S., Obata, Y., Ono, Y., Futatsumata, N., Niimura, S. and Kono, T. Nuclear competence for maturation and pronuclear formation in mouse oocytes. Human Reprod.17, 1311-1316, 2002.
9	Sotomaru, Y., Katsuzawa, Y., Hatada, I., Obata, Y., Sasaki, H. and Kono, T. Unregulated expression of the imprinted Genes H19 and Igf2r in mouse uniparental fetuses. J. Biol. Chem. 277, 12474-12478, 2002.
10	Shimoda, M., Morita, S., Obata, Y., Sotomaru, Y., Kono, T. and Hatada, I. Imprinting of a small nucleolar RNA gene on mouse chromosome 12. Genomics 79, 483-486, 2002.
11	Kono, T., Sotomaru, Y. Katsuzawa, Y. and Dandolo, L. Mouse parthenogenetic embryos with mono-allelic H19 expression can develop to day 17.5 of gestation. Dev. Biol. 243, 294-300, 2002.
12	Obata, Y. and Kono, T. Maternal primary imprinting is established at a specific time for each individual gene throughout oocyte growth. J. Biol. Chem. 277, 5285-5289, 2002.
13	Mizuno, Y., Sotomaru, Y., Katsuzawa, Y., Kono, T., Meguro, M., Oshimura, M., Kawai, J., Tomaru, Y., Kiyozawa, H., Nikaido, I., Amanuma, H., Hayashizaki, Y. and Okazaki, Y. Asb4, Ata3 and dcn are novel imprinted genes identified by high-throughput screening using RIKEN cDNA microarry. BBRC.290, 1499-1505, 2002.
14	Ono, Y., Shimozawa, N., Muguruma, K., Kimoto, S., Hioki, K., Tachibana, M., Shinkai, Y., Ito, M. and Kono, T. Production of cloned mice from embryonic stem cells arrested at metaphase. Reproduction 122, 731-736, 2001.
15	Hatada, I., Morita, S., Obata, Y., Sotomaru, Y., Shimoda, M. and Kono, T. Identification of a new imprinted gene, rian, on mouse chromosome 12 by fluorescent differential display screening. J. Biochem. 130, 187-190, 2001.
16	Sotomaru, Y., Kawase, Y., Obata, Y., Hatada, I. and Kono, T. Disruption of imprinted expression of U2afbp-rs/U2af1-rs1 gene in mouse parthenogenetic fetuses. J. Biol. Chem. 276, 26694-26698, 2001.
17	Ono, Y., Shimozawa, N., Ito, M. and Kono, T. Cloned mice from fetal fibroblast cells arrested at metaphase by a serial nuclear transfer. Biol. Reprod. 64, 44-50, 2001.
18	Ono, Y., Shimozawa, N., Muguruma, K., Kimoto, S., Hioki, K., Tachibana, M., Shinkai, Y., Ito, M. and Kono, T. Production of cloned mice from embryonic stem cells arrested at metaphase. Reproduction 122, 731-736, 2001.
19	Hatada, I., Morita, S., Obata, Y., Sotomaru, Y., Shimoda, M. and Kono, T. Identification of a new imprinted gene, rian, on mouse chromosome 12 by fluorescent differential display screening. J. Biochem. 130, 187-190, 2001.
20	Sotomaru, Y., Kawase, Y., Obata, Y., Hatada, I. and Kono, T. Disruption of imprinted expression of U2afbp-rs/U2af1-rs1 gene in mouse parthenogenetic fetuses. J. Biol. Chem. 276, 26694-26698, 2001.
21	Ono, Y., Shimozawa, N., Ito, M. and Kono, T. Cloned mice from fetal fibroblast cells arrested at metaphase by a serial nuclear transfer. Biol. Reprod. 64, 44-50, 2001.
22	Bao, S., Obata, Y., Carroll, J., Kono, T. Epigenetic modifications necessary for normal development are established during oocyte growth in mice. Biol. Reprod. 62, 616-621, 2000.
23	Obata, Y. Ono, Y., Akuzawa, H., Kwon, O.Y., Yoshizawa, M., Kono, T. Post-implantation developmental of mouse androgenetic embryos produced by in-vitro fertilization of enucleated oocytes. Human Reprod. 15, 874-880, 2000.
24	Tada, T., Obata, Y., Tada, M., Goto, Y., Nakatsuji, N., Tan, S. S., Kono, T., Takagi, N. Imprint switching for non-random X-chromosome inactivation during mouse oocyte growth. Development 127, 3101-3105, 2000.
25	Ueda, T., Abe, K.,Miura, A., Yuzuriha, M., Zubair, M., Noguchi, M., Niwa, K., Kawase, Y., Kono, T., Matsuda, Y., Fujimoto, H., Shibata, H., Hayashizaki, Y., Sasaki, H. The paternal methylation imprint of the H19 locus is acquired in the gonocyte stage during fetal testis development. Genes to Cells 5, 649-659, 2000.
26	Kono, T. Influence of epigenetic changes during oocyte growth on nuclear reprogramming after nuclear transfer. Reprod. Fertil. Dev. 10, 593-598, 1998.
27	Obata, Y., Koneko-Ishino, T., Koide, T., Takai, Y., Ueda, T., Domeki, I., Shiroishi, T., Ishino, F., Kono, T. Disruption of primary imprinting during oocyte growth leads to the modified expression of imprinted genes during embryogenesis. Development 125, 1553-1560, 1998.
28	Kono, T. Nuclear transfer and reprogramming. Reviews of Reproduction 2, 74-80, 1997.
29	Kwon, O.Y. and Kono, T. Production of identical sextuplet mice by transferring metaphase nuclei from four-cell embryos. Proc. Natl. Acad. Sci. USA 93, 13010-1301, 1996.
30	Kono, T., Obata, Y., Yoshimizu, T., Nakahara, T. and Carroll, J. Epigenetic modifications during oocyte growth correlates with extended parthenogenetic development in the mouse. Nature Genetics 13, 91-94, 1996.
31	Kono, T., Jones, K., Bos-Mikich, A., Whittingham, D. and Carroll, J. A cell cycle associated change in Ca2+ releasing activity leads to the generation of Ca2+ transients in mouse embryos during the first mitotic division. J. Cell Biol. 132, 1-9, 1996.
32	K, Jones., J, Carroll., J, Merriman., D, Whitingham., Kono, T. Repetitive sperm-induced Ca2+ transients in mouse oocytes are cell cycle dependent. Development 121, 3259-3266, 1995.
33	Kono, T., Carroll, J., Swann, K., Whittingham, G. Nuclei from fertilized mouse embryos have calcium-releasing activity. Development 121, 1123-1128, 1995.

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