最近の発表論文
最近のダウンロード可能な日本語文献
2024年
Phenotypes for general behavior, activity, and body temperature in 3q29 deletion model mice.
Mori D, Ikeda R, Sawahata M, Yamaguchi S, Kodama A, Hirao T, Arioka Y, Okumura H, Inami C, Suzuki T, Hayashi Y, Kato H, Nawa Y, Miyata S, Kimura H, Kushima I, Aleksic B, Mizoguchi H, Nagai T, Nakazawa T, Hashimoto R, Kaibuchi K, Kume K, Yamada K, Ozaki N. Transl Psychiatry. 2024 Mar 7;14(1):138. doi: 10.1038/s41398-023-02679-w.
https://pubmed.ncbi.nlm.nih.gov/38453903/
Blockade of vasoactive intestinal peptide receptor 2 (VIPR2) signaling suppresses cyclin D1-dependent cell-cycle progression in MCF-7 cells.
Asano S, Ono A, Baba K, Uehara T, Sakamoto K, Hayata-Takano A, Nakazawa T, Yanamoto S, Tanimoto K, Hashimoto H, Ago Y. J Pharmacol Sci. 2024 Mar;154(3):139-147. doi: 10.1016/j.jphs.2024.01.002. Epub 2024 Jan 5.
https://pubmed.ncbi.nlm.nih.gov/38395514/
(R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice.
Yokoyama R, Ago Y, Igarashi H, Higuchi M, Tanuma M, Shimazaki Y, Kawai T, Seiriki K, Hayashida M, Yamaguchi S, Tanaka H, Nakazawa T, Okamura Y, Hashimoto K, Kasai A, Hashimoto H. Mol Psychiatry. 2024 Feb 23. doi: 10.1038/s41380-024-02419-6. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/38388704/
Clozapine Induces Neuronal Activation in the Medial Prefrontal Cortex in a Projection Target-Biased Manner.
Hirato Y, Seiriki K, Kojima L, Yamada S, Rokujo H, Takemoto T, Nakazawa T, Kasai A, Hashimoto H. Biol Pharm Bull. 2024;47(2):478-485. doi: 10.1248/bpb.b23-00898.
https://pubmed.ncbi.nlm.nih.gov/38382927/
Long-lasting anti-despair and anti-anhedonia effects of (S)-norketamine in social isolation-reared mice.
Yokoyama R, Higuchi M, Tanabe W, Tsukada S, Igarashi H, Seiriki K, Nakazawa T, Kasai A, Ago Y, Hashimoto H. J Pharmacol Sci. 2024 Feb;154(2):72-76. doi: 10.1016/j.jphs.2023.12.005. Epub 2023 Dec 14.
https://pubmed.ncbi.nlm.nih.gov/38246730/
Fear memory regulation by the cAMP signaling pathway as an index of reexperiencing symptoms in posttraumatic stress disorder.
Hori H*, Fukushima H*, Nagayoshi T*, Ishikawa R*, Zhuo M, Yoshida F, Kunugi H, Okamoto K, Kim Y, Kida S. (*equal 1st author) Mol Psychiatry. 2024 Feb 27. doi: 10.1038/s41380-024-02453-4. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/38409596/
2023年
Modeling mental disorders in a dish
Nakazawa T. Psychiatry Clin Neurosci. 2023 Jun;77(6):307. doi: 10.1111/pcn.13552. https://pubmed.ncbi.nlm.nih.gov/37259974/
Dorsal raphe serotonergic neurons preferentially reactivate dorsal dentate gyrus cell ensembles associated with positive experience.
Nagai Y, Kisaka Y, Nomura K, Nishitani N, Andoh C, Koda M, Kawai H, Seiriki K, Nagayasu K, Kasai A, Shirakawa H, Nakazawa T, Hashimoto H, Kaneko S. Cell Rep 42:112149 (2023). doi: 10.1016/j.celrep.2023.112149. https://pubmed.ncbi.nlm.nih.gov/36821440/
Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway.
Asano S, Ono A, Sakamoto K, Hayata-Takano A, Nakazawa T, Tanimoto K, Hashimoto H, Ago Y. Peptides 2:170940 (2023). doi: 10.1016/j.peptides.2023.170940. https://pubmed.ncbi.nlm.nih.gov/36603770/
2022年
Vasoactive intestinal peptide-VIPR2 signaling regulates tumor cell migration.
Asano S, Yamasaka M, Ozasa K, Sakamoto K, Hayata-Takano A, Nakazawa T, Hashimoto H, Waschek JA, Ago Y. Front. Oncol. 12:852358 (2022). doi: 10.3389/fonc.2022.852358. https://pubmed.ncbi.nlm.nih.gov/36237322/
Oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome.
Takemoto T, Baba M, Yokoyama K, Kitagawa K, Nagayasu K, Ago Y, Seiriki K, Hayata-Takano A, Kasai A, Mori D, Ozaki N, Takuma K, Hashimoto R, Hashimoto H, Nakazawa T. Mol. Brain 15:26 (2022). doi: 10.1186/s13041-022-00920-z. https://pubmed.ncbi.nlm.nih.gov/35410247/
Autism-associated ANK2 regulates embryonic neurodevelopment.
Kawano S, Baba M, Fukushima H, Miura D, Hashimoto H, Nakazawa T. Biochem. Biophys. Res. Commun. 605:45-50 (2022). doi: 10.1016/j.bbrc.2022.03.058. https://pubmed.ncbi.nlm.nih.gov/35313230/
Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses.
Niu M, Kasai A, Tanuma M, Seiriki K, Igarashi H, Kuwaki T, Nagayasu K, Miyaji K, Ueno H, Tanabe W, Seo K, Yokoyama R, Ohkubo J, Ago Y, Hayashida M, Inoue KI, Takada M, Yamaguchi S, Nakazawa T, Kaneko S, Okuno H, Yamanaka A, Hashimoto H. Sci. Adv. 8:eabi6375 (2022). doi: 10.1126/sciadv.abi6375. https://pubmed.ncbi.nlm.nih.gov/35302853/
Modeling schizophrenia with iPS cell technology and disease mouse models.
Nakazawa T. Neurosci. Res. 175:46-52 (2022). Review. doi: 10.1016/j.neures.2021.08.002. https://pubmed.ncbi.nlm.nih.gov/34411680/
Toward recovery in schizophrenia: Current concepts, findings, and future research directions.
Onitsuka T, Hirano Y, Nakazawa T, Ichihashi K, Miura K, Inada K, Mitoma R, Yasui-Furukori N, Hashimoto R. Psychiatry Clin. Neurosci. 76:282-291 (2022). Review. doi: 10.1111/pcn.13342. https://pubmed.ncbi.nlm.nih.gov/35235256/
Trends in big data analyses by multicenter collaborative translational research in psychiatry.
Onitsuka T, Hirano Y, Nemoto K, Hashimoto N, Kushima I, Koshiyama D, Koeda M, Takahashi T, Noda Y, Matsumoto J, Miura K, Nakazawa T, Hikida T, Kasai K, Ozaki N, Hashimoto R. Psychiatry Clin. Neurosci. 76:1-14 (2022). https://pubmed.ncbi.nlm.nih.gov/34716732/
2021年
PACAP-PAC1 signaling regulates serotonin 2A receptor internalization.
Hayata-Takano A, Shintani Y, Moriguchi K, Encho N, Kitagawa K, Nakazawa T, Hashimoto H. Front. Endocrinol. 12:732456 (2021). doi: 10.3389/fendo.2021.732456. https://pubmed.ncbi.nlm.nih.gov/34759890/
Multiple alterations in glutamatergic transmission and dopamine D2 receptor splicing in induced pluripotent stem cell-derived neurons from patients with familial schizophrenia.
Yamamoto K, Kuriu T, Matsumura K, Nagayasu K, Tsurusaki Y, Miyake N, Yamamori H, Yasuda Y, Fujimoto M, Fujiwara M, Baba M, Kitagawa K, Takemoto T, Gotoda-Nishimura N, Takada T, Seiriki K, Hayata-Takano A, Kasai A, Ago Y, Kida S, Takuma K, Ono F, Matsumoto N, Hashimoto R, Hashimoto H, Nakazawa T. Transl. Psychiatry 11:548 (2021). doi: 10.1038/s41398-021-01676-1. https://pubmed.ncbi.nlm.nih.gov/34697299/
Postsynaptic structure formation of human iPS cell-derived neurons takes longer than presynaptic formation during neural differentiation in vitro.
Togo K, Fukusumi H, Shofuda T, Ohnishi H, Yamazaki H, Hayashi MK, Kawasaki N, Takei N, Nakazawa T, Saito Y, Baba K, Hashimoto H, Sekino Y, Shirao T, Mochizuki H, Kanemura Y. Mol. Brain 14:149 (2021). doi: 10.1186/s13041-021-00851-1. https://pubmed.ncbi.nlm.nih.gov/34629097/
Methylation analysis in monozygotic twins with treatment-resistant schizophrenia and discordant responses to clozapine.
Kikuchi M, Nakazawa T, Kinoshita M, Yamamori H, Yasuda Y, Fujimoto M, Hashimoto R, Numata S. Front. Psychiatry 12:734606 (2021). doi: 10.3389/fpsyt.2021.734606. https://pubmed.ncbi.nlm.nih.gov/34616320/
An autism-associated Neuroligin-3 mutation affects developmental synapse elimination in the cerebellum.
Lai ESK, Nakayama H, Miyazaki T, Nakazawa T, Tabuchi K, Hashimoto K, Watababe M, Kano M. Front. Neural Circuits 15:676891 (2021). doi: 10.3389/fncir.2021.676891. https://pubmed.ncbi.nlm.nih.gov/34262438/
Intranasal oxytocin administration ameliorates social behavioral deficits in a POGZWT/Q1038R mouse model of autism spectrum disorder.
Kitagawa K, Matsumura K, Baba M, Kondo M, Takemoto T, Nagayasu K, Ago Y, Seiriki K, Hayata-Takano A, Kasai A, Takuma K, Hashimoto R, Hashimoto H, Nakazawa T. Mol. Brain 14:56 (2021). doi: 10.1186/s13041-021-00769-8. https://pubmed.ncbi.nlm.nih.gov/33726803/
Tumor necrosis factor alpha negatively regulates the retrieval and reconsolidation of hippocampus-dependent memory.
Takahashi S, Fukushima H, Yu Z, Tomita H, Kida S. Brain Behav Immun. 94:79-88 (2021). doi: 10.1016/j.bbi.2021.02.033. https://pubmed.ncbi.nlm.nih.gov/33677026/
Interactions between the amygdala and medial prefrontal cortex as upstream regulators of the hippocampus to reconsolidate and enhance retrieved inhibitory avoidance memory.
Fukushima H, Zhang Y, Kida S. Mol Brain. 14:44 (2021). doi: 10.1186/s13041-021-00753-2. https://pubmed.ncbi.nlm.nih.gov/33653368/
Active Transition of Fear Memory Phase from Reconsolidation to Extinction through ERK-Mediated Prevention of Reconsolidation.
Fukushima H, Zhang Y, Kida S. J Neurosci. 41:1288-1300. (2021) doi: 10.1523/JNEUROSCI.1854-20.2020. https://pubmed.ncbi.nlm.nih.gov/33293359/
2020年
Lipocaine-type prostaglandin D synthase regulates light-induced phase advance of the central circadian rhythm in mice.
Kawaguchi C, Shintani N, Hayata-Takano A, Hatanaka M, Kuromi A, Nakamura R, Yamamo Y, Shintani Y, Nagai K, Tsuchiya S, Sugimoto Y, Ichikawa A, Okuno Y, Urade Y, Hirai H, Nagata Ky, Nakamura M, Narumiya S, Nakazawa T, Kasai A, Ago Y, Takuma K, Baba A, Hashimoto H. Commun. Biol. 3:557 (2020). doi: 10.1038/s42003-020-01281-w. https://pubmed.ncbi.nlm.nih.gov/33033338/
Activation of the VPAC2 receptor impairs axon outgrowth and decreases dendritic arborization in mouse cortical neurons by a PKA-dependent mechanism.
Takeuchi S, Kawanai T, Yamauchi R, Chen L, Miyaoka T, Yamada M, Asano S, Hayata-Takano A, Nakazawa T, Yano K, Horiguchi N, Nakagawa S, Takuma K, Waschek JA, Hashimoto H, Ago Y. Front. Mol. Neurosci. 14:521 (2020). doi: 10.3389/fnins.2020.00521. https://pubmed.ncbi.nlm.nih.gov/32581681/
Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes.
Matsumura K, Seiriki K, Okada S, Nagase M, Ayabe S, Yamada I, Furuse T, Shibuya H, Yasuda Y, Yamamori H, Fujimoto M, Nagayasu K, Yamamoto K, Kitagawa K, Miura H, Gotoda-Nishimura N, Igarashi H, Hayashida M, Baba M, Kondo M, Hasebe S, Ueshima K, Kasai A, Ago Y, Hayata-Takano A, Shintani N, Iguchi T, Sato M, Yamaguchi S, Tamura M, Wakana S, Yoshiki A, Watabe AM, Okano H, Takuma K, Hashimoto R, Hashimoto H, Nakazawa T. Nat. Commun. 11:859 (2020). doi: 10.1038/s41467-020-14697-z. https://pubmed.ncbi.nlm.nih.gov/32103003/
(S)-norketamine and (2S,6S)-hydroxynorketamine exert potent antidepressant-like effects in a chronic corticosterone-induced mouse model of depression.
Yokoyama R, Higuchi M, Tanabe W, Tsukada S, Naito M, Yamaguchi T, Chen L, Kasai A, Seiriki K, Nakazawa T, Nakagawa S, Hashimoto K, Hashimoto H, Ago Y. Pharmacol. Biochem. Behav. 191:172876 (2020). doi: 10.1016/j.pbb.2020.172876. https://pubmed.ncbi.nlm.nih.gov/32088360/
2019年以前の中澤教授の主要論文
Modeling of psychiatric disorders using induced pluripotent stem cell-related technologies.
Nakazawa T, Hashimoto R, Takuma K, Hashimoto H. J. Pharmacol. Sci. 140:321-324 (2019). Review. doi: 10.1016/j.jphs.2019.06.002. https://pubmed.ncbi.nlm.nih.gov/31257060/
Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome.
Baba M, Yokoyama K, Seiriki K, Naka Y, Matsumura K, Kondo M, Yamamoto K, Hayashida M, Kasai A, Ago Y, Nagayasu K, Hayata-Takano A, Takahashi A, Yamaguchi S, Mori D, Ozaki N, Yamamoto T, Takuma K, Hashimoto R, Hashimoto H, Nakazawa T. Neuropsychopharmacol. 44:2125-2135 (2019). doi: 10.1038/s41386-019-0441-5. https://pubmed.ncbi.nlm.nih.gov/31216562/
Whole-brain block-face serial microscopy tomography at subcellular resolution using FAST.
Seiriki K, Kasai A, Nakazawa T, Niu M, Naka Y, Tanuma M, Igarashi H, Yamaura K, Hayata-Takano A, Ago Y, Hashimoto H. Nat. Protocols 14:1509-1529 (2019). doi: 10.1038/s41596-019-0148-4. https://pubmed.ncbi.nlm.nih.gov/30962606/
Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum.
Choo M, Miyazaki T, Yamasaki M, Kawamura M, Nakazawa T, Zhang J, Tanimura A, Uesaka N, Watanabe M, Sakimura K, Kano M. Nat. Commun. 8:195 (2017). doi: 10.1038/s41467-017-00260-w. https://pubmed.ncbi.nlm.nih.gov/28775326/
High-speed and scalable whole-brain imaging in rodents and primates.
Seiriki K, Kasai A, Hashimoto T, Schulze W, Niu M, Yamaguchi S, Nakazawa T, Inoue K, Uezono S, Takada M, Naka Y, Igarashi H, Tanuma M, Waschek JA, Ago Y, Tanaka KF, Hayata-Takano A, Nagayasu K, Shintani N, Hashimoto R, Kunii Y, Hino M, Matsumoto J, Yabe H, Nagai T, Fujita K, Matsuda T, Takuma K, Baba A, Hashimoto H. Neuron 94:1085-1100 (2017). doi: 10.1016/j.neuron.2017.05.017. https://pubmed.ncbi.nlm.nih.gov/28641108/
Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine.
Nakazawa T, Kikuchi M, Ishikawa M, Yamamori H, Nagayasu K, Matsumoto T, Fujimoto M, Yasuda Y, Fujiwara M, Okada S, Matsumura K, Kasai A, Hayata-Takano A, Shintani N, Numata S, Takuma K, Akamatsu W, Okano H, Nakaya A, Hashimoto H, Hashimoto R. Schizo. Res. 181:75-82 (2017). doi: 10.1016/j.schres.2016.10.012. https://pubmed.ncbi.nlm.nih.gov/28277309/
De novo POGZ mutations in sporadic autism disrupt the DNA-binding activity of POGZ.
Matsumura K, Nakazawa T (CA), Nagayasu K, Gotoda-Nishimura N, Kasai A, Hayata-Takano A, Shintani N, Yamamori H, Yasuda Y, Hashimoto R, Hashimoto H . (CA, corresponding author) J. Mol. Psychiatry 4:1 (2016). doi: 10.1186/s40303-016-0016-x. https://pubmed.ncbi.nlm.nih.gov/27103995/
Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders.
Nakazawa T (CA), Hashimoto R (CA), Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, Ohi K, Yamamori H, Yasuda Y, Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Yokoyama K, Inoue T, Numata S, Ohnuma T, Iwata N, Ozaki N, Hashimoto H, Watanabe M, Manabe T, Yamamoto T, Takeda M, Kano M (CA). (CA, equal corresponding author) Nat. Commun. 7:10594 (2016). doi: 10.1038/ncomms10594. https://pubmed.ncbi.nlm.nih.gov/26839058/
Whole-exome sequencing and neurite outgrowth analysis in autism spectrum disorder.
Hashimoto R (CA), Nakazawa T (CA), Tsurusaki Y, Yasuda Y, Nagayasu K, Matsumura K, Kawasaki H, Yamamori H, Fujimoto M, Ohi K, Umeda-Yano S, Fukunaga M, Fujino H, Kasai A, Hayata-Takano A, Shintani N, Takeda M, Matsumoto N, Hashimoto H. (CA, equal corresponding author) J. Hum. Genet. 61:199-206 (2016). doi: 10.1038/jhg.2015.141. https://pubmed.ncbi.nlm.nih.gov/26582266/
Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain.
Uesaka N, Uchigashima M, Mikuni T, Nakazawa T, Nakao H, Hirai H, Aiba A, Watanabe M, Kano M. Science 344:1020-1023 (2014). doi: 10.1126/science.1252514. https://pubmed.ncbi.nlm.nih.gov/24831527/
Protocadherin 17 regulates presynaptic assembly in topographic corticobasal ganglia circuits.
Hoshina N, Tanimura A, Yamasaki M, Inoue T, Fukabori R, Kuroda T, Yokoyama K, Tezuka T, Sagara H, Hirano S, Kiyonari H, Takada M, Kobayasho K, Watanabe M, Kano M, Nakazawa T, Yamamoto T. Neuron 78:839-854 (2013). doi: 10.1016/j.neuron.2013.03.031. https://pubmed.ncbi.nlm.nih.gov/23684785/
Metaplasticity gated through differential regulation of GluN2A versus GluN2B receptors by Src family kinases.
Yang K, Trepanier C, Sidhu B, Xie YF, Li H, Lei G, Salter MW, Orser BA, Nakazawa T, Yamamoto T, Jackson MF, MacDonald JF. EMBO J. 31:805-816 (2012). doi: 10.1038/emboj.2011.453. https://pubmed.ncbi.nlm.nih.gov/22187052/
NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons.
Yokoyama K, Tezuka T, Kotani M, Nakazawa T, Hoshina N, Shimoda Y, Kakuta S, Sudo K, Watanabe K, Iwakura Y, Yamamoto T. EMBO J. 30:4739-4754 (2011). doi: 10.1038/emboj.2011.348. https://pubmed.ncbi.nlm.nih.gov/21946561/
Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour.
Taniguchi S*, Nakazawa T*(CA), Tanimura A*, Kiyama Y, Tezuka T, Watabe AM, Katayama N, Yokoyama K, Inoue T, Izumi-Nakaseko H, Kakuta S, Sudo K, Iwakura Y, Umemori H, Inoue T, Murphy NP, Hashimoto K, Kano M, Manabe T, Yamamoto, T. (* equal 1st author) (CA, corresponding author) EMBO J. 28:3717-3729 (2009). doi: 10.1038/emboj.2009.300. https://pubmed.ncbi.nlm.nih.gov/19834457/
microRNA modulation of circadian-clock period and entrainment.
Cheng HY, Papp JW, Varlamova O, Dziema H, Russell B, Curfman JP, Nakazawa T, Shimizu K, Okamura H, Impey S, Obrietan K. Neuron 54:813-829 (2007). doi: 10.1016/j.neuron.2007.05.017. https://pubmed.ncbi.nlm.nih.gov/17553428/
NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity.
Nakazawa T*, Komai S*, Watabe AM*, Kiyama Y, Fukaya M, Arima-Yoshida F, Horai R, Sudo K, Ebine K, Delawary M, Goto J, Umemori H, Tezuka T, Iwakura Y, Watanabe M, Yamamoto T, Manabe T. (*equal 1st author) EMBO J. 25:2867-2877 (2006). doi: 10.1038/sj.emboj.7601156. https://pubmed.ncbi.nlm.nih.gov/16710293/
Azoospermia in mice with targeted disruption of the Brek/Lmtk2 (brain-enriched kinase/lemur tyrosine kinase 2) gene.
Kawa S, Ito C, Toyama Y, Maekawa M, Tezuka T, Nakamura T, Nakazawa T, Yokoyama K, Yoshida N, Toshimori K, Yamamoto T. Proc. Natl. Acad. Sci. USA 103:19344-19349 (2006). doi: 10.1073/pnas.0603603103. https://pubmed.ncbi.nlm.nih.gov/17158803/